Our R&D Backgroung

SABC-HLP is led by biotechnology pioneers whose scientific journey mirrors the global evolution of biotechnology—from early breakthroughs in embryo technologies, cryobiology, and somatic cloning to the current era of stem cell science, gene engineering, and regenerative medicine (https://vnsabc.com). By continuously integrating the latest advances in life sciences into its research and innovation ecosystem, SABC-HLP combines decades of proven expertise with next-generation technologies to accelerate precision medicine, healthy longevity, and transformative cellular therapies.

From Embryonic to Stem Cell Technology

SABC-HLP experts and collaborators have led and contributed to numerous national and international initiatives applying advanced technologies to biodiversity conservation, livestock development, and biomedical innovation. Through extensive R&D and technology transfer programs, we have built strong partnerships with leading institutions across Europe, North America, and Asia

1978–1986 | Establishing Reproductive Biotechnology
Laid the scientific foundation for reproductive biotechnology through pioneering embryo transfer research in experimental and domestic animals, creating core expertise in embryology and assisted reproduction.

1983 | Advancing Cryobiology
Developed innovative embryo cryopreservation technologies, including the world's first successful rapid embryo freezing method following room-temperature dehydration, establishing long-term capabilities in cryobiology and biological preservation.

1998–2000 | Building Cloning & Cell Reprogramming Technologies
Expanded research into somatic cell nuclear transfer (SCNT) and interspecies cloning, advancing cell reprogramming technologies while supporting biodiversity conservation and future regenerative medicine applications.

1999 | Translating Reproductive Technologies to Healthcare
Established Vietnam's first successful semen cryobanking application for clinical infertility treatment, marking an important transition from laboratory research to medical application.

2000 | Expanding Advanced Cryopreservation Platforms
Advanced embryo vitrification technologies for cloned embryos, strengthening technical capabilities in cryopreservation and supporting future developments in regenerative biotechnology.

2002 | Developing In Vitro Assisted Reproductive Technologies
Established integrated in vitro embryo production, embryo sexing, and embryo transfer technologies, further expanding expertise in reproductive biotechnology and translational research.

2005 | Entering the Stem Cell Era
Launched pioneering stem cell research in Vietnam, establishing core scientific capabilities in embryonic stem cell biology and contributing to the development of a national vision for stem cell research and technology.

2010–2015 | Building Translational Stem Cell Infrastructure
National Project on cryopreservation and differentiation of human mesenchymal stem cells. Expanded from fundamental research to technology development by establishing key scientific resources, including a human stem cell bank, advancing stem cell isolation and differentiation technologies, and laying the foundation for translational regenerative medicine.

2016–Present | Building a Regional Innovation Ecosystem
Established and continues to develop the Stem Cell & Regenerative Medicine Network (SABC-HLP), integrating stem cell research, biobanking, GMP-cGMP technology platforms, clinical translation, biomanufacturing, industry partnerships, and international collaboration to accelerate regenerative medicine in Vietnam and across Southeast Asia.

Scientific Milestones & Achievements

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Signaling Pathways Impact on Induction of Corneal Epithelial-like Cells Derived from Human Wharton's Jelly Mesenchymal Stem Cells

Hong Thi Nguyen 1 2, Kasem Theerakittayakorn 1, Sirilak Somredngan 1,..., Ruttachuk Rungsiwiwut 8, Chuti Laowtammathron 9, Nguyen Xuan Bui 10, Rangsun Parnpai 1

Int J Mol Sci. 2022 Mar 12;23(6):3078.

The combination of RA, SB505124, BMP4, and EGF for the first 3 days of differentiation followed by supplementing hormonal epidermal medium for an additional 6 days could generate corneal epithelial-like cells that expressed a CEC specific marker CK12. This study reveals that WJ-MSCs have the potential to transdifferentiate into CECs which would be beneficial for further applications in LSCD treatment therapy.

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

Hiroyuki Matsumura, Yasuaki Mohri, Nguyen Thanh Binh, Hironobu Morinaga, Makoto Fukuda, Mayumi Ito, Sotaro Kurata, Jan Hoeijmakers, and Emi K. Nishimura

Quiescent and aging hair follicle stem cells

Stem cells enable normal cell homeostasis, but they also exist in a quiescent state, ready to proliferate and differentiate after tissue damage. Now, two studies reveal features of stem cells in the hair follicle, an epithelial mini-organ of the skin that is responsible for hair growth and recycling (see the Perspective by Chuong and Lei). Wang et al. found that the Foxc1 transcription factor is induced in activated hair follicle stem cells, which in turn promote Nfatc1 and BMP signaling, to reinforce quiescence. Matsumura et al. analyzed hair follicle stem cells during aging. They identified type XVII collagen (COL17A1) as key to hair thinning. DNA damage-induced depletion of COL17A1 triggered cell differentiation resulting in the shedding of epidermal keratinocytes from the skin surface. These changes then caused hair follicle shrinkage and hair loss.

Science, this issue p. 559, p. 613; see also p. 10.1126/science.aad4395

INTERNATIONAL SCIENTIFIC SEMINAR ON "DISEASES ASSOCIATED WITH AGENT ORANGE/DIOXIN EXPOSURE IN VIETNAM - CURRENT SITUATION AND SOLUTIONS TO IMPROVE EFFECTIVENESS OF PREVENTION AND TREATMENT"

Monday, 20 December 2021

Identification of biomarkers for dioxin exposure and dioxin-associated cancer susceptibility

Thi My Anh NEILDEZ-NGUYEN1,2, Xuan Nguyen BUI3

1 Centre de Recherche Saint-Antoine, INSERM UMRS 938, Sorbonne Université, Paris, France.

2 EPHE, PSL University, Paris, France.

3 South-East Asian Biotechnology Center, Hanoi, Vietnam.

Abstract

Dioxins are environmental pollutants that can accumulate in human tissue through the food chain. Exposure to 2,3,7,8-Tetrachlorodibenzo-para-dioxin (TCDD), the most toxic dioxin, as a contaminant in the defoliant Agent Orange, dumped during the Viet